Human ATP Binding Cassette Transporter A1 (ABCA1) ELISA Kit
689€ (96 tests)
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name
Human ATP Binding Cassette Transporter A1 (ABCA1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx150498
tested applications
ELISA
Description
Human ATP Binding Cassette Transporter A1 (ABCA1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ATP Binding Cassette Transporter A1 (ABCA1) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of ATP Binding Cassette Transporter A1 (ABCA1)
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | ATP Binding Cassette Transporter A1 (ABCA1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O95477 |
| Gene ID | 19 |
| OMIM | 205400 |
| Alias | TGD,ABC1,CERP,ABC-1,HDLDT1,HPALP1,HDLCQTL13 |
| Background | Elisa kits for ABCA1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ABCA1 is a transmembrane protein belonging to the ATP-binding cassette (ABC) transporter family, playing a vital role in lipid metabolism and cellular cholesterol efflux. It facilitates the transport of cholesterol and phospholipids from cells to apolipoproteins, such as ApoA-I, in the plasma, which is a critical step in the formation of high-density lipoprotein (HDL). Structurally, ABCA1 consists of two transmembrane domains and two ATP-binding domains that utilize ATP hydrolysis to drive lipid transport. It is highly expressed in macrophages, hepatocytes, and other cells involved in lipid metabolism. The activity of ABCA1 is essential for maintaining cellular cholesterol homeostasis and preventing lipid accumulation, particularly in macrophages, where its dysfunction can lead to foam cell formation and atherosclerosis. Mutations in the ABCA1 gene are associated with Tangier disease, a rare disorder characterized by very low HDL levels and increased susceptibility to cardiovascular disease. As a key regulator of cholesterol efflux and HDL biogenesis, ABCA1 is a therapeutic target for managing dyslipidemia and cardiovascular risk.
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