Human ATP Binding Cassette Subfamily B Member 7 (ABCB7) Protein
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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein ABCB7
proveedor
Abbexareference
abx650381Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human ABCB7 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ABCB7 is a mitochondrial transporter essential for the biogenesis of iron-sulfur clusters, which are critical cofactors for enzymes involved in cellular respiration, DNA repair, and metabolic processes. ABCB7 facilitates the export of iron-sulfur cluster intermediates from mitochondria to the cytosol, a key step in ensuring proper assembly and function of cytosolic and nuclear iron-sulfur proteins. Highly expressed in metabolically active tissues, such as the liver, bone marrow, and red blood cells, ABCB7 plays a vital role in maintaining iron homeostasis and mitochondrial function. Mutations in the ABCB7 gene are linked to X-linked sideroblastic anemia with ataxia, characterized by defective hemoglobin synthesis, neurological impairments, and mitochondrial dysfunction. Additionally, ABCB7 has been implicated in oxidative stress responses, highlighting its broader role in cellular protection and energy regulation. Its functions in iron-sulfur cluster assembly and export underscore its critical importance in mitochondrial and cellular health.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
ATP Binding Cassette Subfamily B Member 7 (ABCB7)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 34.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val472-Cys752 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCB7
dry ice
No
availability
Shipped within 5-7 working days.
alias
ABC7,ASAT,Atm1p,EST140535
uniprot id
NCBI accession
NP_001258625.1, NM_001271696.1
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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