ATP Binding Cassette Subfamily B Member 7 (ABCB7) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Rabbit polyclonal antibody against ABCB7 protein. Immunogen region is C-terminal.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily B Member 7 (ABCB7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, IHC: 1/50 - 1/100, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75027 |
| Gene ID | 22 |
| NCBI Accession | NP_001258625.1, NM_001271696.1 |
| OMIM | 300135 |
| Alias | ABC7,ASAT,Atm1p,EST140535 |
| Background | Antibody anti-ABCB7 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ABCB7 is a mitochondrial transporter essential for the biogenesis of iron-sulfur clusters, which are critical cofactors for enzymes involved in cellular respiration, DNA repair, and metabolic processes. ABCB7 facilitates the export of iron-sulfur cluster intermediates from mitochondria to the cytosol, a key step in ensuring proper assembly and function of cytosolic and nuclear iron-sulfur proteins. Highly expressed in metabolically active tissues, such as the liver, bone marrow, and red blood cells, ABCB7 plays a vital role in maintaining iron homeostasis and mitochondrial function. Mutations in the ABCB7 gene are linked to X-linked sideroblastic anemia with ataxia, characterized by defective hemoglobin synthesis, neurological impairments, and mitochondrial dysfunction. Additionally, ABCB7 has been implicated in oxidative stress responses, highlighting its broader role in cellular protection and energy regulation. Its functions in iron-sulfur cluster assembly and export underscore its critical importance in mitochondrial and cellular health.
Related Products
ABCB7 antibody
Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur(Fe/S) cluster-containing proteins.
Ver Producto
ATP Binding Cassette Subfamily B Member 7 (ABCB7) Antibody
Rabbit polyclonal antibody against ABCB7 protein. Immunogen region is C-terminal.
Ver Producto
ATP Binding Cassette Subfamily B Member 7 (ABCB7) Antibody
The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
Ver Producto