Human ATP Binding Cassette Subfamily B Member 7 (ABCB7) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ABCB7
proveedor
Abbexareference
abx385542Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human ATP Binding Cassette Subfamily B Member 7 (ABCB7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ATP Binding Cassette Subfamily B Member 7 (ABCB7) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ABCB7 is a mitochondrial transporter essential for the biogenesis of iron-sulfur clusters, which are critical cofactors for enzymes involved in cellular respiration, DNA repair, and metabolic processes. ABCB7 facilitates the export of iron-sulfur cluster intermediates from mitochondria to the cytosol, a key step in ensuring proper assembly and function of cytosolic and nuclear iron-sulfur proteins. Highly expressed in metabolically active tissues, such as the liver, bone marrow, and red blood cells, ABCB7 plays a vital role in maintaining iron homeostasis and mitochondrial function. Mutations in the ABCB7 gene are linked to X-linked sideroblastic anemia with ataxia, characterized by defective hemoglobin synthesis, neurological impairments, and mitochondrial dysfunction. Additionally, ABCB7 has been implicated in oxidative stress responses, highlighting its broader role in cellular protection and energy regulation. Its functions in iron-sulfur cluster assembly and export underscore its critical importance in mitochondrial and cellular health.
Características del producto
category
ELISA Kits
immunogen target
ATP Binding Cassette Subfamily B Member 7 (ABCB7)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.19 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
ABC7,ASAT,Atm1p,EST140535
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ABCB7
dry ice
No
uniprot id
NCBI accession
NP_001258625.1, NM_001271696.1
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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