Human ATP-Binding Cassette Subfamily B Member 5 (ABCB5) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ABCB5
proveedor
Abbexareference
abx166806Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
ATP Binding Cassette Transporter B5 Protein is a recombinant Human protein expressed in E. coli.
Background
ABCB5 is a transmembrane ATP-binding cassette (ABC) transporter known for its roles in drug resistance, stem cell biology, and tissue repair. It is expressed in a variety of tissues, including melanocytes, the corneal epithelium, and cancer stem cells, particularly in melanoma. ABCB5 functions as a drug efflux pump, actively exporting chemotherapeutic agents out of cells, contributing to multidrug resistance in cancer. It is also a recognized marker of cancer stem cells, promoting tumor growth, metastasis, and resistance to standard therapies. Beyond its role in cancer, ABCB5 has been implicated in wound healing and tissue regeneration due to its expression in progenitor cells in damaged tissues. Structurally, ABCB5 contains transmembrane domains and ATP-binding sites that drive substrate transport through ATP hydrolysis. Dysregulation of ABCB5 is associated with cancer progression, chemoresistance, and impaired tissue repair, making it a promising therapeutic target in oncology and regenerative medicine.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
ATP-Binding Cassette Subfamily B Member 5 (ABCB5)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.1 kDa Observed MW (SDS-PAGE): 30 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu570-Ala808 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCB5
dry ice
No
availability
Shipped within 5-7 working days.
alias
ABCB5alphabeta,EST422562
uniprot id
NCBI accession
NP_001157413.1, NM_001163941.1, NP_001157414.1, NM_001163942.1, NP_001157465.1, NM_001163993.2, NP_848654.3, NM_178559.5
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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