Human ATP-Binding Cassette Subfamily B Member 5 (ABCB5) Protein

Este producto es parte de ABCB - ATP binding cassette subfamily B member
Human ATP-Binding Cassette Subfamily B Member 5 (ABCB5) Protein

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935106861

info@markelab.com

Precio

234€ (10 µg)

Protein ABCB5

proveedor

Abbexa

reference

abx166806

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

ATP Binding Cassette Transporter B5 Protein is a recombinant Human protein expressed in E. coli.


Background

ABCB5 is a transmembrane ATP-binding cassette (ABC) transporter known for its roles in drug resistance, stem cell biology, and tissue repair. It is expressed in a variety of tissues, including melanocytes, the corneal epithelium, and cancer stem cells, particularly in melanoma. ABCB5 functions as a drug efflux pump, actively exporting chemotherapeutic agents out of cells, contributing to multidrug resistance in cancer. It is also a recognized marker of cancer stem cells, promoting tumor growth, metastasis, and resistance to standard therapies. Beyond its role in cancer, ABCB5 has been implicated in wound healing and tissue regeneration due to its expression in progenitor cells in damaged tissues. Structurally, ABCB5 contains transmembrane domains and ATP-binding sites that drive substrate transport through ATP hydrolysis. Dysregulation of ABCB5 is associated with cancer progression, chemoresistance, and impaired tissue repair, making it a promising therapeutic target in oncology and regenerative medicine.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

ATP-Binding Cassette Subfamily B Member 5 (ABCB5)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 30.1 kDa Observed MW (SDS-PAGE): 30 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu570-Ala808 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCB5


dry ice

No


availability

Shipped within 5-7 working days.


alias

ABCB5alphabeta,EST422562


NCBI accession

NP_001157413.1, NM_001163941.1, NP_001157414.1, NM_001163942.1, NP_001157465.1, NM_001163993.2, NP_848654.3, NM_178559.5


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reactivity

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status

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clonality

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ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins pa...

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