ATP-Binding Cassette Subfamily B Member 5 (ABCB5) Antibody
383.5€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
ATP-Binding Cassette Subfamily B Member 5 (ABCB5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx010341
tested applications
ELISA, IHC, IF/ICC, FCM
Description
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-Binding Cassette Subfamily B Member 5 (ABCB5) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q2M3G2 |
| Gene ID | 340273 |
| NCBI Accession | NM_178559.5 |
| OMIM | 611785 |
| Alias | ABCB5alphabeta,EST422562 |
| Background | Antibody anti-ABCB5 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ABCB5 is a transmembrane ATP-binding cassette (ABC) transporter known for its roles in drug resistance, stem cell biology, and tissue repair. It is expressed in a variety of tissues, including melanocytes, the corneal epithelium, and cancer stem cells, particularly in melanoma. ABCB5 functions as a drug efflux pump, actively exporting chemotherapeutic agents out of cells, contributing to multidrug resistance in cancer. It is also a recognized marker of cancer stem cells, promoting tumor growth, metastasis, and resistance to standard therapies. Beyond its role in cancer, ABCB5 has been implicated in wound healing and tissue regeneration due to its expression in progenitor cells in damaged tissues. Structurally, ABCB5 contains transmembrane domains and ATP-binding sites that drive substrate transport through ATP hydrolysis. Dysregulation of ABCB5 is associated with cancer progression, chemoresistance, and impaired tissue repair, making it a promising therapeutic target in oncology and regenerative medicine.
Related Products
Human ABCB5 (ATP-binding cassette sub-family B member 5) ELISA Kit
Ver Producto
ABCB5 antibody
Ver Producto