Human ATP Binding Cassette Subfamily B Member 4 (ABCB4) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human ATP Binding Cassette Subfamily B Member 4 (ABCB4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx250423
tested applications
ELISA
Description
Human ATP Binding Cassette Subfamily B Member 4 (ABCB4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Multidrug resistance protein 3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | ATP Binding Cassette Subfamily B Member 4 (ABCB4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P21439 |
| Gene ID | 5244 |
| Alias | ABC21,GBD1,ICP3,MDR2,MDR2/3,MDR3,PFIC-3,PGY3 |
| Background | Elisa kits for ABCB4 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ABCB4, also known as MDR3, is expressed on the canalicular membrane of hepatocytes and plays a pivotal role in bile formation by mediating the ATP-dependent translocation of phosphatidylcholine into bile. Phosphatidylcholine protects bile ducts from the detergent effects of bile salts, ensuring proper bile composition and preventing bile-related liver damage. Mutations in ABCB4 are associated with progressive familial intrahepatic cholestasis type 3 (PFIC3), low phospholipid-associated cholelithiasis (LPAC), and other cholestatic liver diseases. Dysregulation of ABCB4 leads to bile duct injury, inflammation, and fibrosis, ultimately resulting in liver dysfunction. As a critical regulator of bile composition, ABCB4 is a significant focus in the study of liver health and diseases related to bile metabolism.
Related Products
Human ABCB4 (Multidrug resistance protein 3) ELISA Kit
Ver Producto
Human ABCB4 (Multidrug resistance protein 3) QuickTest ELISA Kit
Ver Producto
ATP Binding Cassette Transporter B4 (ABCB4) Antibody (Biotin)
ATP Binding Cassette Transporter B4 (ABCB4) Antibody (Biotin) is a Rabbit Polyclonal antibody against ATP Binding Cassette Transporter B4 (ABCB4) conjugated to Biotin.
Ver Producto