Human ATP-binding cassette sub-family B member 8, mitochondrial (ABCB8) ELISA Kit

715€ (96 tests)
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935106861
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name
Human ATP-binding cassette sub-family B member 8, mitochondrial (ABCB8) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500429
tested applications
ELISA
Description
Human ATP-binding cassette sub-family B member 8, mitochondrial (ABCB8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ATP-binding cassette sub-family B member 8, mitochondrial (ABCB8) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | ATP-binding cassette sub-family B member 8, mitochondrial (ABCB8) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9NUT2 |
| Alias | EST328128,M-ABC1,MABC1,MITOSUR |
| Background | Elisa Kits for: ABCB8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
ABCB8 is a mitochondrial ATP-binding cassette transporter involved in the export of iron-sulfur cluster intermediates and possibly other substrates from mitochondria to the cytosol. This function is critical for maintaining cellular iron homeostasis, facilitating the proper assembly of iron-sulfur cluster-containing proteins, and regulating oxidative stress. ABCB8 is highly expressed in metabolically active tissues, such as the heart, skeletal muscle, and liver, where mitochondrial function is crucial. Dysregulation of ABCB8 can lead to mitochondrial iron overload, contributing to oxidative damage and cellular dysfunction, particularly in cardiomyocytes. Emerging evidence suggests that ABCB8 plays a protective role in maintaining mitochondrial integrity under stress conditions, making it an important factor in cardiovascular health and mitochondrial-related diseases.
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