Human Glucosylceramide Transporter ABCA12 (ABCA12) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ABCA12
proveedor
Abbexareference
abx500420Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Glucosylceramide Transporter ABCA12 (ABCA12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Glucosylceramide Transporter ABCA12 (ABCA12) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ABCA12 (ATP-binding cassette sub-family A member 12) is a member of the ATP-binding cassette (ABC) transporter superfamily, which is responsible for translocating a wide variety of molecules across cellular membranes. ABCA12 is crucial for the proper transport of lipids, particularly glucosylceramides, in the epidermis. These lipids play an essential role in forming the skin’s barrier function, protecting against environmental insults and preventing water loss. ABCA12 is highly expressed in keratinocytes within the epidermis, particularly in the granular layer, where it facilitates the secretion of lipids into lamellar bodies. These organelles are essential for maintaining the integrity of the stratum corneum, the outermost layer of the skin. Dysregulation or mutations in the ABCA12 gene can result in severe skin disorders, most notably Harlequin ichthyosis (HI), a rare but devastating congenital condition.
Características del producto
category
ELISA Kits
immunogen target
Glucosylceramide Transporter ABCA12 (ABCA12)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.12 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
ARCI4A,ARCI4B,ICR2B,LI2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ABCA12
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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