Human Aryl Hydrocarbon Receptor Repressor (AHRR) Protein

Pida mas información
935106861
info@markelab.com
Precio
234€ (10 µg)
Protein AHRR
proveedor
Abbexareference
abx650769Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human AHRR Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
AHRR is a transcriptional repressor that negatively regulates the AHR signaling pathway. It is induced by AHR activation as part of a negative feedback loop and functions by competing with AHR for dimerization with ARNT or binding to XREs to inhibit AHR-mediated transcription. AHRR is expressed in various tissues, including the liver, lungs, and immune cells, and is involved in maintaining the balance of AHR activity, preventing excessive or prolonged responses to environmental toxins. Dysregulation of AHRR has been associated with cancer, particularly in lung cancer and gastric cancer, where reduced AHRR expression leads to enhanced AHR activity and tumor-promoting effects. In addition to its role in xenobiotic detoxification, AHRR also participates in regulating immune responses and maintaining cellular homeostasis, with emerging evidence highlighting its involvement in inflammation and metabolic disorders.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Aryl Hydrocarbon Receptor Repressor (AHRR)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 50.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Pro182 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
AHRR
dry ice
No
availability
Shipped within 5-7 working days.
alias
AHH,AHHR,bHLHe77
uniprot id
NCBI accession
NP_001229341.1, NM_001242412.1
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Aryl Hydrocarbon Receptor Repressor (AHRR) Antibody

proveedor
Abbexareference
abx037882Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalRabbit Polyclonal against the AHRR protein.
357.5€ (100 µg)
Ver másAryl Hydrocarbon Receptor Repressor (AHRR) Antibody

proveedor
Abbexareference
abx130625Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalAHRR Antibody is a Rabbit Polyclonal against AHRR.
286€ (100 µl)
Ver másHuman Aryl Hydrocarbon Receptor Repressor (AHRR) ELISA Kit

proveedor
Abbexareference
abx150596Tested Applications
ELISAreactivity
Humanstatus
RUOHuman Aryl Hydrocarbon Receptor Repressor (AHRR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of ...
715€ (96 tests)
Ver más