Human Aryl Hydrocarbon Receptor Repressor (AHRR) Protein

Este producto es parte de AHR - Aryl hydrocarbon receptor (repressor)
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234€ (10 µg)

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935106861
info@markelab.com
name
Human Aryl Hydrocarbon Receptor Repressor (AHRR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650769
tested applications
WB, SDS-PAGE

Description

Human AHRR Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Aryl Hydrocarbon Receptor Repressor (AHRR)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 50.4 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met1-Pro182
Tag: N-terminal His tag and GST tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
A9YTQ3
Gene ID
57491
NCBI Accession
NP_001229341.1, NM_001242412.1
OMIM
606517
Alias
AHH,AHHR,bHLHe77
Background
Protein AHRR
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

AHRR is a transcriptional repressor that negatively regulates the AHR signaling pathway. It is induced by AHR activation as part of a negative feedback loop and functions by competing with AHR for dimerization with ARNT or binding to XREs to inhibit AHR-mediated transcription. AHRR is expressed in various tissues, including the liver, lungs, and immune cells, and is involved in maintaining the balance of AHR activity, preventing excessive or prolonged responses to environmental toxins. Dysregulation of AHRR has been associated with cancer, particularly in lung cancer and gastric cancer, where reduced AHRR expression leads to enhanced AHR activity and tumor-promoting effects. In addition to its role in xenobiotic detoxification, AHRR also participates in regulating immune responses and maintaining cellular homeostasis, with emerging evidence highlighting its involvement in inflammation and metabolic disorders.

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