Human Aryl Hydrocarbon Receptor Repressor (AHRR) Protein

Este producto es parte de AHR - Aryl hydrocarbon receptor (repressor)
Human Aryl Hydrocarbon Receptor Repressor (AHRR) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein AHRR

proveedor

Abbexa

reference

abx650769

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human AHRR Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

AHRR is a transcriptional repressor that negatively regulates the AHR signaling pathway. It is induced by AHR activation as part of a negative feedback loop and functions by competing with AHR for dimerization with ARNT or binding to XREs to inhibit AHR-mediated transcription. AHRR is expressed in various tissues, including the liver, lungs, and immune cells, and is involved in maintaining the balance of AHR activity, preventing excessive or prolonged responses to environmental toxins. Dysregulation of AHRR has been associated with cancer, particularly in lung cancer and gastric cancer, where reduced AHRR expression leads to enhanced AHR activity and tumor-promoting effects. In addition to its role in xenobiotic detoxification, AHRR also participates in regulating immune responses and maintaining cellular homeostasis, with emerging evidence highlighting its involvement in inflammation and metabolic disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Aryl Hydrocarbon Receptor Repressor (AHRR)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 50.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Pro182 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

AHRR


dry ice

No


availability

Shipped within 5-7 working days.


alias

AHH,AHHR,bHLHe77


NCBI accession

NP_001229341.1, NM_001242412.1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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