Aryl Hydrocarbon Receptor Repressor (AHRR) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Aryl Hydrocarbon Receptor Repressor (AHRR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130625
tested applications
WB, IHC, IF/ICC
Description
AHRR Antibody is a Rabbit Polyclonal against AHRR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aryl Hydrocarbon Receptor Repressor (AHRR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A9YTQ3 |
| Gene ID | 57491 |
| NCBI Accession | NP_001229341.1, NM_001242412.1 |
| OMIM | 606517 |
| Alias | AHH,AHHR,bHLHe77 |
| Background | Antibody anti-AHRR |
| Status | RUO |
Descripción
AHRR is a transcriptional repressor that negatively regulates the AHR signaling pathway. It is induced by AHR activation as part of a negative feedback loop and functions by competing with AHR for dimerization with ARNT or binding to XREs to inhibit AHR-mediated transcription. AHRR is expressed in various tissues, including the liver, lungs, and immune cells, and is involved in maintaining the balance of AHR activity, preventing excessive or prolonged responses to environmental toxins. Dysregulation of AHRR has been associated with cancer, particularly in lung cancer and gastric cancer, where reduced AHRR expression leads to enhanced AHR activity and tumor-promoting effects. In addition to its role in xenobiotic detoxification, AHRR also participates in regulating immune responses and maintaining cellular homeostasis, with emerging evidence highlighting its involvement in inflammation and metabolic disorders.
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