Human Arf-GAP With GTPase, ANK Repeat And PH Domain Containing Protein 2 (AGAP2) ELISA Kit
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Description
Human Arf-GAP With GTPase, ANK Repeat And PH Domain Containing Protein 2 (AGAP2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human AGAP2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Arf-GAP With GTPase, ANK Repeat And PH Domain Containing Protein 2 (AGAP2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q99490 |
| Gene ID | 116986 |
| OMIM | 605476 |
| Alias | CENTG1,GGAP2,PIKE |
| Background | Elisa kits for AGAP2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AGAP2, also known as PIKE-A, plays a key role in regulating cell survival, growth signaling pathways, and intracellular transport. It interacts with phosphoinositide 3-kinase (PI3K), enhancing PI3K-Akt signaling and promoting anti-apoptotic responses. AGAP2 contains a GTPase domain, ankyrin repeats, and a PH domain, enabling its participation in vesicle trafficking, cytoskeletal dynamics, and endosomal transport. It is expressed in neurons, where it supports synaptic stability and neuronal survival, and is overexpressed in cancers such as glioblastomas, driving tumor growth and resistance to apoptosis. AGAP2’s dual roles in neuronal plasticity and oncogenesis make it a significant target for therapeutic research.
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