Human Apolipoprotein O (APOO) Protein
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Description
Apolipoprotein O Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Apolipoprotein O (APOO) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 23.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys26-Lys198 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | MIC26,MICOS26,FAM121B,My025,MIC23,Apolipoprotein O |
| Background | Protein APOO |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Apolipoprotein O (APOO) is a lipid-associated protein that is primarily involved in lipid metabolism, mitochondrial function, and cardiovascular health. APOO is widely expressed in the heart, liver, skeletal muscle, and adipose tissues, where it associates with circulating lipoproteins such as high-density lipoproteins (HDL) and very-low-density lipoproteins (VLDL). APOO plays a critical role in modulating mitochondrial function and energy metabolism by influencing mitochondrial membrane integrity and regulating reactive oxygen species (ROS) production. Additionally, APOO has been implicated in the formation and secretion of lipoproteins, as well as the trafficking of cholesterol and triglycerides. Altered APOO expression has been observed in metabolic and cardiovascular diseases, including obesity, insulin resistance, and atherosclerosis, where it contributes to lipid accumulation, mitochondrial dysfunction, and oxidative stress. Recent findings suggest APOO may also play a role in regulating cellular responses to hypoxia and energy stress, highlighting its importance in maintaining cellular and mitochondrial homeostasis. As a key mediator of lipid metabolism and mitochondrial function, APOO is an emerging target for research into the prevention and treatment of metabolic disorders, cardiovascular diseases, and oxidative stress-related conditions. Further investigation is needed to fully elucidate APOO’s mechanisms and therapeutic potential in lipid homeostasis and mitochondrial health.
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