Apolipoprotein O (APOO) Antibody
292.5€ (80 µl)
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Name
Apolipoprotein O (APOO) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx027343
Tested Applications
ELISA, WB, IHC
Description
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Apolipoprotein O (APOO) Immunogen: KLH-conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human APOO. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 22.3 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BUR5 |
| Alias | MIC26,MICOS26,FAM121B,My025,MIC23,Apolipoprotein O |
| Background | Antibody anti-APOO |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Apolipoprotein O (APOO) is a lipid-associated protein that is primarily involved in lipid metabolism, mitochondrial function, and cardiovascular health. APOO is widely expressed in the heart, liver, skeletal muscle, and adipose tissues, where it associates with circulating lipoproteins such as high-density lipoproteins (HDL) and very-low-density lipoproteins (VLDL). APOO plays a critical role in modulating mitochondrial function and energy metabolism by influencing mitochondrial membrane integrity and regulating reactive oxygen species (ROS) production. Additionally, APOO has been implicated in the formation and secretion of lipoproteins, as well as the trafficking of cholesterol and triglycerides. Altered APOO expression has been observed in metabolic and cardiovascular diseases, including obesity, insulin resistance, and atherosclerosis, where it contributes to lipid accumulation, mitochondrial dysfunction, and oxidative stress. Recent findings suggest APOO may also play a role in regulating cellular responses to hypoxia and energy stress, highlighting its importance in maintaining cellular and mitochondrial homeostasis. As a key mediator of lipid metabolism and mitochondrial function, APOO is an emerging target for research into the prevention and treatment of metabolic disorders, cardiovascular diseases, and oxidative stress-related conditions. Further investigation is needed to fully elucidate APOO’s mechanisms and therapeutic potential in lipid homeostasis and mitochondrial health.
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