Human Apolipoprotein H (APOH) Protein
364€ (20 µg)
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name
Human Apolipoprotein H (APOH) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691503
tested applications
SDS-PAGE
Description
Human ApolipoProtein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human APOH (NP_000033.2) (Met 1-Cys 345) was expressed, with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Apolipoprotein H (APOH) |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 37.7 kDa Sequence Fragment: Met1-Cys345 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 96% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_000033.2 |
| Alias | APOH, B2G1, B2GP1, BG, apolipoprotein H,β2-glycoprotein 1,beta-2 glycoprotein 1 ,Apolipoprotein H |
| Background | Protein APOH |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Apolipoprotein H (APOH), also known as β2-glycoprotein I, is a multifunctional glycoprotein involved in lipid transport, coagulation, and immune regulation. APOH is primarily synthesized in the liver and circulates in the bloodstream, where it binds to phospholipids and lipoproteins, particularly VLDL and chylomicrons. APOH has a significant role in antiphospholipid syndrome (APS), an autoimmune disorder characterized by the presence of antiphospholipid antibodies that interfere with blood clotting. APOH interacts with anionic phospholipids and influences coagulation pathways, contributing to its function as a regulator of hemostasis and thrombosis. It also participates in lipid metabolism, facilitating the clearance of triglyceride-rich lipoproteins by binding to receptors on hepatocytes. Beyond its role in coagulation, APOH has immunological functions, such as modulating inflammatory responses and pathogen recognition, positioning it as a key player in the innate immune system. Elevated APOH levels have been associated with autoimmune diseases, cardiovascular disorders, and infectious diseases, underscoring its role in both homeostasis and disease progression. APOH’s diverse activities, including its interactions with lipids, immune factors, and coagulation pathways, make it an essential protein in physiology and a potential therapeutic target in autoimmune and thrombotic diseases.
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