APOH antibody
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Name
APOH antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00510
Tested Applications
ELISA, WB, IHC
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | apolipoprotein H(beta-2-glycoprotein I) (APOH) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:1000-1:4000; IHC: 1:100-1:500 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | 4E8 |
| Observed MW | 43-55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P02749 |
| Gene ID | 350 |
| Alias | APOH, B2G1, B2GP1, BG, apolipoprotein H,β2-glycoprotein 1,beta-2 glycoprotein 1 ,Apolipoprotein H |
| Background | Antibody anti-APOH |
| Status | RUO |
| Note | Mol. Weight 43-55 kDa |
Background
Apolipoprotein H (APOH), also known as β2-glycoprotein I, is a multifunctional glycoprotein involved in lipid transport, coagulation, and immune regulation. APOH is primarily synthesized in the liver and circulates in the bloodstream, where it binds to phospholipids and lipoproteins, particularly VLDL and chylomicrons. APOH has a significant role in antiphospholipid syndrome (APS), an autoimmune disorder characterized by the presence of antiphospholipid antibodies that interfere with blood clotting. APOH interacts with anionic phospholipids and influences coagulation pathways, contributing to its function as a regulator of hemostasis and thrombosis. It also participates in lipid metabolism, facilitating the clearance of triglyceride-rich lipoproteins by binding to receptors on hepatocytes. Beyond its role in coagulation, APOH has immunological functions, such as modulating inflammatory responses and pathogen recognition, positioning it as a key player in the innate immune system. Elevated APOH levels have been associated with autoimmune diseases, cardiovascular disorders, and infectious diseases, underscoring its role in both homeostasis and disease progression. APOH’s diverse activities, including its interactions with lipids, immune factors, and coagulation pathways, make it an essential protein in physiology and a potential therapeutic target in autoimmune and thrombotic diseases.
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