Human Anoctamin 6 (ANO6) Protein
221€ (10 µg)
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935106861
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name
Human Anoctamin 6 (ANO6) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166620
tested applications
WB, SDS-PAGE
Description
Anoctamin 6 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Anoctamin 6 (ANO6) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 13.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala744-Asn824 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ANO6,TMEM16F |
| Background | Protein ANO6 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ANO6, also known as TMEM16F, is a dual-function protein acting as a calcium-activated phospholipid scramblase and ion channel. It plays a critical role in plasma membrane repair, cell death (apoptosis), and blood coagulation by regulating the externalization of phosphatidylserine (PS), a process essential for platelet activation and membrane remodeling. ANO6 is expressed in various tissues, including the hematopoietic system, skeletal muscle, and immune cells. Mutations in ANO6 cause Scott syndrome, a rare bleeding disorder characterized by impaired PS exposure on platelet surfaces, which disrupts proper blood clotting. ANO6 also contributes to cellular responses to mechanical stress, apoptosis, and bone development. Its roles in membrane repair and phospholipid scrambling underscore its importance in cell survival, homeostasis, and coagulation.
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