Anoctamin 6 (ANO6) Antibody
286€ (100 µl)
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name
Anoctamin 6 (ANO6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx128357
tested applications
WB, IHC, IF/ICC
Description
Anoctamin 6 Antibody is a Rabbit Polyclonal against Anoctamin 6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anoctamin 6 (ANO6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q4KMQ2 |
| Alias | ANO6,TMEM16F |
| Background | Antibody anti-ANO6 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ANO6, also known as TMEM16F, is a dual-function protein acting as a calcium-activated phospholipid scramblase and ion channel. It plays a critical role in plasma membrane repair, cell death (apoptosis), and blood coagulation by regulating the externalization of phosphatidylserine (PS), a process essential for platelet activation and membrane remodeling. ANO6 is expressed in various tissues, including the hematopoietic system, skeletal muscle, and immune cells. Mutations in ANO6 cause Scott syndrome, a rare bleeding disorder characterized by impaired PS exposure on platelet surfaces, which disrupts proper blood clotting. ANO6 also contributes to cellular responses to mechanical stress, apoptosis, and bone development. Its roles in membrane repair and phospholipid scrambling underscore its importance in cell survival, homeostasis, and coagulation.
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