Human Anoctamin 2 (ANO2) Protein

Background

ANO2, or TMEM16B, is another calcium-activated chloride channel (CaCC) predominantly expressed in sensory neurons and olfactory tissues. ANO2 plays a vital role in olfactory transduction, where it contributes to the depolarization of sensory neurons in response to odorant stimulation. Beyond the olfactory system, ANO2 is involved in regulating neuronal excitability and signal transmission in the central nervous system, including brain regions related to sensory processing. Dysregulation of ANO2 function can impair sensory perception and may contribute to olfactory disorders and neurodegenerative conditions. Its precise role in ion homeostasis and neuronal signaling makes it an important target for understanding sensory transduction and related diseases.