ANO2 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
ANO2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00442
tested applications
ELISA, WB, IF, IP, IHC
Description
Calcium-activated chloride channel(CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors(OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | anoctamin 2 (ANO2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:1000-1:10000; IHC: 1:20-1:200; IF: 1:10-1:100; IP: 1:200-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 114 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IP, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NQ90 |
| Gene ID | 57101 |
| Alias | ANO2,C12orf3,TMEM16B |
| Background | Antibody anti-ANO2 |
| Status | RUO |
| Note | Mol. Weight 114 kDa |
Descripción
ANO2, or TMEM16B, is another calcium-activated chloride channel (CaCC) predominantly expressed in sensory neurons and olfactory tissues. ANO2 plays a vital role in olfactory transduction, where it contributes to the depolarization of sensory neurons in response to odorant stimulation. Beyond the olfactory system, ANO2 is involved in regulating neuronal excitability and signal transmission in the central nervous system, including brain regions related to sensory processing. Dysregulation of ANO2 function can impair sensory perception and may contribute to olfactory disorders and neurodegenerative conditions. Its precise role in ion homeostasis and neuronal signaling makes it an important target for understanding sensory transduction and related diseases.
Related Products
ANO2 antibody
Calcium-activated chloride channel(CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors(OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
Ver Producto
Anoctamin-2 (ANO2) Antibody
ANO2 Antibody is a Rabbit Polyclonal antibody against ANO2. ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009.
Ver Producto
Anoctamin 2 (ANO2) Antibody
Anoctamin 2 Antibody is a Rabbit Polyclonal antibody against Anoctamin 2.
Ver Producto