Human Annexin A4 (ANXA4) Protein
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Description
Recombinant Annexin A4 (ANXA4) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Annexin A4 (ANXA4) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 18.4 kDa Observed MW (SDS-PAGE): 19 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys11-Glu164 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_001153.3 |
| Alias | ANXA4,ANX4,Annexin IV,Annexin-4 |
| Background | Protein ANXA4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ANXA4 is a calcium-dependent phospholipid-binding protein that participates in membrane repair, ion channel regulation, and signal transduction. It is predominantly expressed in epithelial tissues, particularly in the gastrointestinal tract, kidneys, and lungs, where it regulates cellular processes such as endocytosis and exocytosis. ANXA4 plays a role in calcium signaling, contributing to ion transport and epithelial barrier function. Overexpression of ANXA4 has been observed in cancers such as ovarian, breast, and gastric cancers, where it promotes tumor cell migration and chemoresistance. Its role in maintaining membrane integrity and ion balance highlights its importance in epithelial homeostasis and tumor progression.
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Annexin IV /placental anticoagulant protein II(ANX4) is a member of the annexin or lipocortin family of calcium-dependent phospholipid binding proteins, and is located at 2p13. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 shares 45 to 59% identity with other members and possibly interacts with ATP. ANX4 has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. In western blotting, we get 36 kDa, 39 kDa(with modification), and 60 kDa(an unspecifc band).
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Annexin IV /placental anticoagulant protein II(ANX4) is a member of the annexin or lipocortin family of calcium-dependent phospholipid binding proteins, and is located at 2p13. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 shares 45 to 59% identity with other members and possibly interacts with ATP. ANX4 has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. In western blotting, we get 36 kDa, 39 kDa(with modification), and 60 kDa(an unspecifc band).
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