anti- Annexin IV antibody
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Precio
Precio a consultar
Antibody anti-ANXA4
proveedor
FineTestreference
FNab00434Tested Applications
ELISA, IHC, WBreactivity
human,mouse,ratstatus
RUOclonality
polyclonalDescripción
Annexin IV /placental anticoagulant protein II(ANX4) is a member of the annexin or lipocortin family of calcium-dependent phospholipid binding proteins, and is located at 2p13. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 shares 45 to 59% identity with other members and possibly interacts with ATP. ANX4 has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. In western blotting, we get 36 kDa, 39 kDa(with modification), and 60 kDa(an unspecifc band).
Background
ANXA4 is a calcium-dependent phospholipid-binding protein that participates in membrane repair, ion channel regulation, and signal transduction. It is predominantly expressed in epithelial tissues, particularly in the gastrointestinal tract, kidneys, and lungs, where it regulates cellular processes such as endocytosis and exocytosis. ANXA4 plays a role in calcium signaling, contributing to ion transport and epithelial barrier function. Overexpression of ANXA4 has been observed in cancers such as ovarian, breast, and gastric cancers, where it promotes tumor cell migration and chemoresistance. Its role in maintaining membrane integrity and ion balance highlights its importance in epithelial homeostasis and tumor progression.
Características del producto
category
Primary Antibodies
clonality
polyclonal
reactivity
human,mouse,rat
immunogen target
annexin A4
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
liquid
tested applications
ELISA, IHC, WB
observerd MW
36 kDa
purity
≥95% as determined by SDS-PAGE
purification
Immunogen affinity purified
recommended dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
ANXA4
alias
ANXA4,ANX4,Annexin IV,Annexin-4
uniprot id
note
This product is for research use only.
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