Name: anti- Annexin IV antibody
Brand: FineTest
SKU: FNab00435
Availability: OnlineOnly

Descripción

Annexin IV /placental anticoagulant protein II(ANX4) is a member of the annexin or lipocortin family of calcium-dependent phospholipid binding proteins, and is located at 2p13. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 shares 45 to 59% identity with other members and possibly interacts with ATP. ANX4 has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. In western blotting, we get 36 kDa, 39 kDa(with modification), and 60 kDa(an unspecifc band).

Background

ANXA4 is a calcium-dependent phospholipid-binding protein that participates in membrane repair, ion channel regulation, and signal transduction. It is predominantly expressed in epithelial tissues, particularly in the gastrointestinal tract, kidneys, and lungs, where it regulates cellular processes such as endocytosis and exocytosis. ANXA4 plays a role in calcium signaling, contributing to ion transport and epithelial barrier function. Overexpression of ANXA4 has been observed in cancers such as ovarian, breast, and gastric cancers, where it promotes tumor cell migration and chemoresistance. Its role in maintaining membrane integrity and ion balance highlights its importance in epithelial homeostasis and tumor progression.

Características del producto

clonality

monoclonal

reactivity

human

immunogen target

annexin A4

host

Mouse

isotype

IgG2c

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC

observerd MW

32 kDa

purity

≥95% as determined by SDS-PAGE

purification

Protein A+G purification

recommended dilution

WB: 1:500-1:5000; IHC: 1:50-1:500; IF: 1:50-1:500

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

ANXA4

alias

ANXA4,ANX4,Annexin IV,Annexin-4

uniprot id

https://www.uniprot.org/uniprotkb/P09525

note

This product is for research use only.

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proveedor

FineTest

reference

EH1904

reactivity

human

status

RUO

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