Human Angiopoietin-Related Protein 1 (ANGPTL1) Protein
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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein ANGPTL1
proveedor
Abbexareference
abx065325Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Angiopoietin-Related Protein 1 (ANGPTL1) Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ANGPTL1 is a member of the angiopoietin-like (ANGPTL) protein family, which regulates diverse biological processes, including angiogenesis, inflammation, and metabolism, although it does not interact with the Tie2 receptor like classical angiopoietins. ANGPTL1 functions as a tumor suppressor by inhibiting angiogenesis and cancer cell migration. It blocks endothelial cell proliferation and tube formation, reducing blood vessel growth within the tumor microenvironment. ANGPTL1 also regulates cell adhesion and extracellular matrix stability, contributing to tissue homeostasis and integrity. Reduced expression of ANGPTL1 has been observed in several cancers, including lung, liver, and colorectal cancers, where its loss is associated with tumor progression, metastasis, and poor prognosis. ANGPTL1 also plays a role in inhibiting inflammatory responses, linking it to immune regulation and vascular integrity. Its function as an anti-angiogenic and anti-tumor factor highlights ANGPTL1 as a promising therapeutic target for cancer treatment and vascular diseases.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Angiopoietin-Related Protein 1 (ANGPTL1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 27.0 kDa Observed MW (SDS-PAGE): 27 kDa Concentration: Prior to lyophilization: 400 µg/ml Sequence Fragment: Phe271-Asp491 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ANGPTL1
dry ice
No
availability
Shipped within 5-12 working days.
alias
ANG3,ANGPT3,ARP1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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