Human Angiopoietin-Related Protein 1 (ANGPTL1) Protein

Este producto es parte de ANGPTL - Angiopoietin Like
Human Angiopoietin-Related Protein 1 (ANGPTL1) Protein

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935106861

info@markelab.com

Precio

208€ (10 µg)

Protein ANGPTL1

proveedor

Abbexa

reference

abx065325

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Angiopoietin-Related Protein 1 (ANGPTL1) Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ANGPTL1 is a member of the angiopoietin-like (ANGPTL) protein family, which regulates diverse biological processes, including angiogenesis, inflammation, and metabolism, although it does not interact with the Tie2 receptor like classical angiopoietins. ANGPTL1 functions as a tumor suppressor by inhibiting angiogenesis and cancer cell migration. It blocks endothelial cell proliferation and tube formation, reducing blood vessel growth within the tumor microenvironment. ANGPTL1 also regulates cell adhesion and extracellular matrix stability, contributing to tissue homeostasis and integrity. Reduced expression of ANGPTL1 has been observed in several cancers, including lung, liver, and colorectal cancers, where its loss is associated with tumor progression, metastasis, and poor prognosis. ANGPTL1 also plays a role in inhibiting inflammatory responses, linking it to immune regulation and vascular integrity. Its function as an anti-angiogenic and anti-tumor factor highlights ANGPTL1 as a promising therapeutic target for cancer treatment and vascular diseases.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Angiopoietin-Related Protein 1 (ANGPTL1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 27.0 kDa Observed MW (SDS-PAGE): 27 kDa Concentration: Prior to lyophilization: 400 µg/ml Sequence Fragment: Phe271-Asp491 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ANGPTL1


dry ice

No


availability

Shipped within 5-12 working days.


alias

ANG3,ANGPT3,ARP1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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