Angiopoietin-Related Protein 1 (ANGPTL1) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Angiopoietin-Related Protein 1 (ANGPTL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037839
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ANGPTL1 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Angiopoietin-Related Protein 1 (ANGPTL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_004673 |
| Alias | ANG3,ANGPT3,ARP1 |
| Background | Antibody anti-ANGPTL1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ANGPTL1 is a member of the angiopoietin-like (ANGPTL) protein family, which regulates diverse biological processes, including angiogenesis, inflammation, and metabolism, although it does not interact with the Tie2 receptor like classical angiopoietins. ANGPTL1 functions as a tumor suppressor by inhibiting angiogenesis and cancer cell migration. It blocks endothelial cell proliferation and tube formation, reducing blood vessel growth within the tumor microenvironment. ANGPTL1 also regulates cell adhesion and extracellular matrix stability, contributing to tissue homeostasis and integrity. Reduced expression of ANGPTL1 has been observed in several cancers, including lung, liver, and colorectal cancers, where its loss is associated with tumor progression, metastasis, and poor prognosis. ANGPTL1 also plays a role in inhibiting inflammatory responses, linking it to immune regulation and vascular integrity. Its function as an anti-angiogenic and anti-tumor factor highlights ANGPTL1 as a promising therapeutic target for cancer treatment and vascular diseases.
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