Human Anaphase-promoting complex subunit 11 (ANAPC11) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Anaphase-promoting complex subunit 11 (ANAPC11) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx502106
tested applications
ELISA
Description
Human Anaphase-promoting complex subunit 11 (ANAPC11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase-promoting complex subunit 11 (ANAPC11) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Anaphase-promoting complex subunit 11 (ANAPC11) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9NYG5 |
| Alias | ANAPC11,HSPC214,Cyclosome subunit 11 |
| Background | Elisa kits for ANAPC11 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ANAPC11 is the catalytic RING finger subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), where it facilitates the ubiquitin transfer activity of the complex. As an E3 ubiquitin ligase, ANAPC11 directly interacts with E2 ubiquitin-conjugating enzymes to catalyze the ubiquitination of cell cycle regulators such as cyclin B and securin, promoting their degradation via the proteasome. This process is critical for initiating anaphase, regulating mitotic exit, and maintaining genomic stability. ANAPC11 is essential for APC/C activity, and its loss or inhibition results in mitotic arrest, aneuploidy, and cell cycle defects. Mutations or dysregulation of ANAPC11 have been associated with cancer progression, as impaired proteolysis of APC/C substrates can lead to uncontrolled proliferation and chromosomal instability. ANAPC11’s catalytic function makes it a central component of APC/C and a potential target for cancer therapies aimed at disrupting mitotic progression in tumor cells.
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