Human Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Protein

Este producto es parte de AIMP - Aminoacyl tRNA synthetase complex interacting multifunctional protein
Human Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Protein
832€ (50 µg)

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Name
Human Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx655556
Tested Applications
WB, SDS-PAGE

Description

Human Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Protein (Active) is an Active recombinant Human protein.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1)
Assay Type
Activity: Active
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 90%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
p43,HLD3,EMAP2,SCYE1,EMAPII
Background
Protein AIMP1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

AIMP1, also known as EMAP II (Endothelial Monocyte-Activating Polypeptide II), is a multifunctional protein that acts as a core component of the multi-aminoacyl-tRNA synthetase complex (MSC), which is essential for protein synthesis. It interacts with various aminoacyl-tRNA synthetases to maintain the stability and functionality of the complex. Beyond its role in translation, AIMP1 has extracellular signaling functions, particularly in modulating immune responses and angiogenesis. When secreted, AIMP1 functions as a cytokine that activates monocytes and endothelial cells, contributing to inflammatory responses and tissue repair. It is also involved in apoptosis, cellular stress responses, and tumor suppression. Dysregulation of AIMP1 is associated with cancer progression, inflammatory diseases, and autoimmune disorders, highlighting its dual roles in intracellular protein synthesis and extracellular signaling.

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