Human Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Protein
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935106861
info@markelab.com
Precio
260€ (10 µg)
Protein AIMP1
proveedor
Abbexareference
abx065290Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
AIMP1, also known as EMAP II (Endothelial Monocyte-Activating Polypeptide II), is a multifunctional protein that acts as a core component of the multi-aminoacyl-tRNA synthetase complex (MSC), which is essential for protein synthesis. It interacts with various aminoacyl-tRNA synthetases to maintain the stability and functionality of the complex. Beyond its role in translation, AIMP1 has extracellular signaling functions, particularly in modulating immune responses and angiogenesis. When secreted, AIMP1 functions as a cytokine that activates monocytes and endothelial cells, contributing to inflammatory responses and tissue repair. It is also involved in apoptosis, cellular stress responses, and tumor suppression. Dysregulation of AIMP1 is associated with cancer progression, inflammatory diseases, and autoimmune disorders, highlighting its dual roles in intracellular protein synthesis and extracellular signaling.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 19.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys148-Lys312 Tag: N-terminal His tag
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
AIMP1
dry ice
No
availability
Shipped within 5-12 working days.
alias
p43,HLD3,EMAP2,SCYE1,EMAPII
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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