Human Aldolase C, Fructose Bisphosphate (ALDOC) Protein
234€ (5 µg)
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935106861
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name
Human Aldolase C, Fructose Bisphosphate (ALDOC) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx073197
tested applications
SDS-PAGE
Description
Aldolase C Fructose-Bisphosphate is a recombinant enzyme.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aldolase C, Fructose Bisphosphate (ALDOC) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09972 |
| Alias | ALDOC,ALDC |
| Background | Protein ALDOC |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ALDOC is a brain-specific isoform of fructose-bisphosphate aldolase that catalyzes the same glycolytic reaction as ALDOA and ALDOB, converting fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. ALDOC is highly expressed in the central nervous system (CNS), particularly in astrocytes and Purkinje cells of the cerebellum, where it plays a key role in brain energy metabolism and glucose utilization. Altered expression or mutations in ALDOC are linked to neurodegenerative disorders and gliomas, where energy metabolism is disrupted. Additionally, ALDOC is involved in maintaining neuronal function and astrocyte homeostasis under normal and stress conditions. Its critical role in glycolysis makes it essential for supporting brain function and energy demands.
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Fructose-bisphosphate aldolase C(ALDOC) reversibly cleaves FBP and F1-P to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate and is strongly expressed in mammalian brain together with ALDOA and is alsopresent in the heart and spleen of some species(PMID:9363598). It is involed in glycolysis as an important enzyme. Phospholipase D2 and inositol 1,4,5-triphosphate interact with ALDOC in signal transduction. Meanwhile, the protein expression of ALDOC has been reported to be regulated in brain tumor, hepatomas, and lung cancer(PMID:21548097).
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