Human Aldo-keto reductase family 1 member C-like protein 1 (AKR1C8P) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Aldo-keto reductase family 1 member C-like protein 1 (AKR1C8P) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501425
tested applications
ELISA
Description
Human Aldo-keto reductase family 1 member C-like protein 1 (AKR1C8P) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Aldo-keto reductase family 1 member C-like protein 1 (AKR1C8P) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Aldo-keto reductase family 1 member C-like protein 1 (AKR1C8P) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q5T2L2 |
| Alias | AKR1C8, AKR1C8P, AKR1CL1 |
| Background | Elisa kits for AKR1C8 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKR1C8 is a member of the AKR1C subfamily that shares significant sequence and functional similarity with other AKR1C isoforms. It plays a key role in steroid hormone metabolism, particularly in reducing ketosteroids such as androgens and progesterone into their less active 3α-hydroxy derivatives. AKR1C8 is also involved in detoxifying reactive aldehydes, including products of lipid peroxidation such as 4-hydroxynonenal (4-HNE), protecting cells from oxidative damage. While its specific tissue distribution is not yet fully characterized, AKR1C8 likely contributes to maintaining steroid homeostasis and cellular redox balance. Dysregulation of AKR1C8 is suspected to play a role in hormone-dependent cancers, metabolic diseases, and inflammatory conditions, where excessive reactive carbonyls and steroid imbalances contribute to disease pathology. Ongoing research focuses on understanding AKR1C8’s unique activity compared to closely related AKR1C enzymes and its potential as a therapeutic target.
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