Aldo-Keto Reductase Family 1 Member C-Like Protein 1 (AKR1CL1) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Aldo-Keto Reductase Family 1 Member C-Like Protein 1 (AKR1CL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx014169
tested applications
ELISA, IF/ICC
Description
Rabbit polyclonal antibody against AKR1CL1 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member C-Like Protein 1 (AKR1CL1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/100 - 1/500, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5T2L2 |
| Alias | AKR1C8, AKR1C8P, AKR1CL1 |
| Background | Antibody anti-AKR1C8 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AKR1C8 is a member of the AKR1C subfamily that shares significant sequence and functional similarity with other AKR1C isoforms. It plays a key role in steroid hormone metabolism, particularly in reducing ketosteroids such as androgens and progesterone into their less active 3α-hydroxy derivatives. AKR1C8 is also involved in detoxifying reactive aldehydes, including products of lipid peroxidation such as 4-hydroxynonenal (4-HNE), protecting cells from oxidative damage. While its specific tissue distribution is not yet fully characterized, AKR1C8 likely contributes to maintaining steroid homeostasis and cellular redox balance. Dysregulation of AKR1C8 is suspected to play a role in hormone-dependent cancers, metabolic diseases, and inflammatory conditions, where excessive reactive carbonyls and steroid imbalances contribute to disease pathology. Ongoing research focuses on understanding AKR1C8’s unique activity compared to closely related AKR1C enzymes and its potential as a therapeutic target.
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