Human 2-Aminomuconic Semialdehyde Dehydrogenase (ALDH8A1) ELISA Kit

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
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715€ (96 tests)

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935106861
info@markelab.com
name
Human 2-Aminomuconic Semialdehyde Dehydrogenase (ALDH8A1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385709
tested applications
ELISA

Description

Human 2-Aminomuconic Semialdehyde Dehydrogenase (ALDH8A1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Aldehyde Dehydrogenase 8 Family, Member A1 (ALDH8A1) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
2-Aminomuconic Semialdehyde Dehydrogenase (ALDH8A1)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
78 pg/ml - 5000 pg/ml
Sensitivity
< 29 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9H2A2
Gene ID
64577
OMIM
606467
Alias
ALDH8A1,ALDH12
Background
Elisa Kits for: ALDH8A1
Status
RUO
Note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Descripción

ALDH8A1 is a cytosolic enzyme primarily involved in the metabolism of retinaldehyde to retinoic acid, a key signaling molecule that regulates cell differentiation, growth, and tissue homeostasis. ALDH8A1 is expressed in metabolic tissues, including the liver, kidneys, and retina, where it supports retinoid metabolism and vitamin A homeostasis. Its role in converting retinaldehyde to retinoic acid makes ALDH8A1 critical for maintaining vision, embryonic development, and immune responses. Dysregulation of ALDH8A1 has been implicated in retinal diseases, such as age-related macular degeneration (AMD), and developmental abnormalities caused by retinoic acid deficiency. ALDH8A1 also participates in detoxifying aldehydes derived from lipid peroxidation and xenobiotic metabolism, contributing to cellular defense against oxidative stress. Emerging studies suggest its involvement in maintaining retinoid signaling pathways and redox balance.

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