Human Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide (ADH7) Protein
338€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide (ADH7) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690396
tested applications
SDS-PAGE
Description
Human Alcohol Dehydrogenase Class 4 Mu Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Alcohol Dehydrogenase Class 4 Mu/Sigma Chain is produced by our Mammalian expression system and the target gene encoding Met1-Phe386 is expressed with a 6His tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Alcohol Dehydrogenase Class 4 Mu |
| Host | Human |
| Origin | Human |
| Observed MW | Molecular Weight: 42.5 kDa Sequence Fragment: Met1-Phe386 Tag: C-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | PBS, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | P40394 |
| Alias | ADH4,Gastric alcohol dehydrogenase, Retinol dehydrogenase |
| Background | Protein ADH7 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADH7, also known as retinol dehydrogenase 3, is a member of the class IV alcohol dehydrogenase family and is predominantly expressed in the stomach, esophagus, and liver. Unlike other ADH enzymes, ADH7 shows higher activity towards retinol and long-chain alcohols, playing a critical role in retinoic acid biosynthesis, which is essential for cellular differentiation and growth. Its ability to oxidize ethanol is comparatively limited, but it has significant involvement in detoxifying aromatic and aliphatic alcohols, including those derived from dietary sources. ADH7 is highly relevant in protecting mucosal tissues from alcohol-induced damage, particularly in the upper gastrointestinal tract. Genetic polymorphisms affecting ADH7 activity have been linked to variations in susceptibility to alcohol-related cancers, such as esophageal squamous cell carcinoma, due to differences in acetaldehyde accumulation and oxidative stress. Its role in retinoid metabolism also underscores its significance in regulating developmental and immune processes.
Related Products
ADH7 antibody
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain(octanol) and aromatic(m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
Ver Producto
Recombinant Human ADH7
Ver Producto
Alcohol Dehydrogenase Class 4 Mu/Sigma Chain (ADH7) Antibody
ADH7 Antibody is a Rabbit Polyclonal Antibody against ADH7.
Ver Producto