ADH7 antibody
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935106861
info@markelab.com
name
ADH7 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00166
tested applications
ELISA, WB, IF, IHC
Description
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain(octanol) and aromatic(m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | alcohol dehydrogenase 7(class IV), mu or sigma polypeptide (ADH7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:5000; IF: 1:20-1:200; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 45-47 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P40394 |
| Gene ID | 131 |
| Alias | ADH4,Gastric alcohol dehydrogenase, Retinol dehydrogenase |
| Background | Antibody anti-ADH7 |
| Status | RUO |
| Note | Mol. Weight 45-47 kDa |
Descripción
ADH7, also known as retinol dehydrogenase 3, is a member of the class IV alcohol dehydrogenase family and is predominantly expressed in the stomach, esophagus, and liver. Unlike other ADH enzymes, ADH7 shows higher activity towards retinol and long-chain alcohols, playing a critical role in retinoic acid biosynthesis, which is essential for cellular differentiation and growth. Its ability to oxidize ethanol is comparatively limited, but it has significant involvement in detoxifying aromatic and aliphatic alcohols, including those derived from dietary sources. ADH7 is highly relevant in protecting mucosal tissues from alcohol-induced damage, particularly in the upper gastrointestinal tract. Genetic polymorphisms affecting ADH7 activity have been linked to variations in susceptibility to alcohol-related cancers, such as esophageal squamous cell carcinoma, due to differences in acetaldehyde accumulation and oxidative stress. Its role in retinoid metabolism also underscores its significance in regulating developmental and immune processes.
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