Alcohol Dehydrogenase Class 4 Mu/Sigma Chain (ADH7) Antibody
312€ (60 µl)
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Name
Alcohol Dehydrogenase Class 4 Mu/Sigma Chain (ADH7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx005661
Tested Applications
IF/ICC
Description
ADH7 Antibody is a Rabbit Polyclonal Antibody against ADH7.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Alcohol Dehydrogenase Class 4 Mu/Sigma Chain (ADH7) Immunogen: Recombinant fusion protein corresponding to human ADH7 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P40394 |
| Gene ID | 131 |
| NCBI Accession | NP_000664.2 |
| Alias | ADH4,Gastric alcohol dehydrogenase, Retinol dehydrogenase |
| Background | Antibody anti-ADH7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADH7, also known as retinol dehydrogenase 3, is a member of the class IV alcohol dehydrogenase family and is predominantly expressed in the stomach, esophagus, and liver. Unlike other ADH enzymes, ADH7 shows higher activity towards retinol and long-chain alcohols, playing a critical role in retinoic acid biosynthesis, which is essential for cellular differentiation and growth. Its ability to oxidize ethanol is comparatively limited, but it has significant involvement in detoxifying aromatic and aliphatic alcohols, including those derived from dietary sources. ADH7 is highly relevant in protecting mucosal tissues from alcohol-induced damage, particularly in the upper gastrointestinal tract. Genetic polymorphisms affecting ADH7 activity have been linked to variations in susceptibility to alcohol-related cancers, such as esophageal squamous cell carcinoma, due to differences in acetaldehyde accumulation and oxidative stress. Its role in retinoid metabolism also underscores its significance in regulating developmental and immune processes.
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