Human Alcohol Dehydrogenase 6 (Class V) (ADH6) Protein

Background

ADH6 encodes a class V alcohol dehydrogenase, which is expressed in the liver and other tissues but is less well characterized compared to other members of the ADH family. It is believed to participate in the oxidation of ethanol and other alcohols, although its specific substrates and physiological roles remain under investigation. ADH6 shows structural similarities to other ADH enzymes, suggesting potential roles in detoxification and metabolism of alcohols and aldehydes. While its contribution to overall alcohol metabolism may be limited, it may have tissue-specific functions in metabolic pathways. Emerging studies suggest that genetic variations in ADH6 could influence individual differences in alcohol tolerance and susceptibility to alcohol-related disorders. Its role in cellular detoxification processes highlights its potential importance in maintaining metabolic balance and protecting against alcohol-induced oxidative stress. Further research is needed to fully elucidate the functional significance of ADH6 in human physiology.