Human Alanine Glyoxylate Aminotransferase (AGXT) ELISA Kit

715€ (96 tests)
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935106861
info@markelab.com
name
Human Alanine Glyoxylate Aminotransferase (AGXT) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx585265
tested applications
ELISA
Description
Human Alanine Glyoxylate Aminotransferase (AGXT) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Alanine Glyoxylate Aminotransferase (AGXT) concentrations in serum, plasma, tissue homogenates and other biological fluids.
Documents del producto
Product specifications
Category | ELISA Kits |
Immunogen Target | Alanine Glyoxylate Aminotransferase (AGXT) |
Reactivity | Human |
Detection Method | Colorimetric |
Assay Data | Quantitative |
Assay Type | Sandwich |
Test Range | 1.56 ng/ml - 100 ng/ml |
Sensitivity | < 0.59 ng/ml |
Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
Size 1 | 96 tests |
Size 2 | 5 × 96 tests |
Size 3 | 10 × 96 tests |
Form | Lyophilized |
Tested Applications | ELISA |
Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
Dry Ice | No |
Alias | AGXT, AGT1, SPAT |
Background | Elisa kits for AGXT |
Status | RUO |
Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Alanine-glyoxylate aminotransferase (AGXT) is a pyridoxal phosphate-dependent enzyme localized in peroxisomes, where it plays a critical role in detoxifying glyoxylate by converting it into glycine, using alanine as an amino donor. AGXT is central to preventing the overproduction of oxalate, a byproduct of glyoxylate metabolism, which, if accumulated, can form calcium oxalate crystals leading to kidney stones and renal damage. Mutations in the AGXT gene cause primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder characterized by excessive oxalate production, kidney stone formation, and systemic oxalosis. AGXT's activity is regulated by intracellular localization and metabolic cues, and therapies targeting AGXT include enzyme replacement therapy and gene therapy to restore glyoxylate metabolism in affected individuals.
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