Human AKR1C1 (Aldo-keto reductase family 1 member C1) ELISA Kit
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Name
Human AKR1C1 (Aldo-keto reductase family 1 member C1) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH1577
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q04828 |
| Alias | AKR1C1,DDH,DDH1 |
| Background | Elisa kits for AKR1C1 |
| Status | RUO |
Background
AKR1C1, also known as 20α-hydroxysteroid dehydrogenase, is an enzyme involved in the metabolism of steroid hormones, specifically converting progesterone to its inactive metabolite, 20α-dihydroprogesterone. It plays a critical role in maintaining hormone balance and modulating progesterone-dependent signaling pathways, particularly in reproductive tissues. AKR1C1 also participates in the metabolism of androgens, estrogens, and other steroid hormones, influencing cell proliferation and differentiation. Overexpression of AKR1C1 has been implicated in hormone-driven cancers, such as breast, ovarian, and prostate cancers, where it reduces active steroid hormone levels to promote tumor progression. AKR1C1 also metabolizes reactive aldehydes, such as 4-hydroxynonenal (4-HNE), protecting cells from oxidative stress and chemotherapeutic agents. Its involvement in drug resistance highlights AKR1C1 as a potential therapeutic target in cancer treatment. Additionally, AKR1C1 is linked to neurological functions, as it regulates neurosteroids that modulate synaptic transmission and neuroprotection.
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