Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) Antibody
357.5€ (100 µg)
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935106861
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name
Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx036473
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AKR1C1 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AKR1C1,DDH,DDH1 |
| Background | Antibody anti-AKR1C1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
AKR1C1, also known as 20α-hydroxysteroid dehydrogenase, is an enzyme involved in the metabolism of steroid hormones, specifically converting progesterone to its inactive metabolite, 20α-dihydroprogesterone. It plays a critical role in maintaining hormone balance and modulating progesterone-dependent signaling pathways, particularly in reproductive tissues. AKR1C1 also participates in the metabolism of androgens, estrogens, and other steroid hormones, influencing cell proliferation and differentiation. Overexpression of AKR1C1 has been implicated in hormone-driven cancers, such as breast, ovarian, and prostate cancers, where it reduces active steroid hormone levels to promote tumor progression. AKR1C1 also metabolizes reactive aldehydes, such as 4-hydroxynonenal (4-HNE), protecting cells from oxidative stress and chemotherapeutic agents. Its involvement in drug resistance highlights AKR1C1 as a potential therapeutic target in cancer treatment. Additionally, AKR1C1 is linked to neurological functions, as it regulates neurosteroids that modulate synaptic transmission and neuroprotection.
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