Human Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) Enzyme
234€ (5 µg)
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Name
Human Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) Enzyme
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073111
Tested Applications
SDS-PAGE
Description
Aldo-Keto Reductase Family 1 Member C1 is a recombinant enzyme.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q04828 |
| Alias | AKR1C1,DDH,DDH1 |
| Background | Protein AKR1C1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKR1C1, also known as 20α-hydroxysteroid dehydrogenase, is an enzyme involved in the metabolism of steroid hormones, specifically converting progesterone to its inactive metabolite, 20α-dihydroprogesterone. It plays a critical role in maintaining hormone balance and modulating progesterone-dependent signaling pathways, particularly in reproductive tissues. AKR1C1 also participates in the metabolism of androgens, estrogens, and other steroid hormones, influencing cell proliferation and differentiation. Overexpression of AKR1C1 has been implicated in hormone-driven cancers, such as breast, ovarian, and prostate cancers, where it reduces active steroid hormone levels to promote tumor progression. AKR1C1 also metabolizes reactive aldehydes, such as 4-hydroxynonenal (4-HNE), protecting cells from oxidative stress and chemotherapeutic agents. Its involvement in drug resistance highlights AKR1C1 as a potential therapeutic target in cancer treatment. Additionally, AKR1C1 is linked to neurological functions, as it regulates neurosteroids that modulate synaptic transmission and neuroprotection.
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