Human AKAP17A (A-kinase anchor protein 17A) ELISA Kit
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Name
Human AKAP17A (A-kinase anchor protein 17A) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH1213
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q02040 |
| Alias | 721P,AKAP-17A,CCDC133 |
| Background | Elisa kits for AKAP17A |
| Status | RUO |
Background
AKAP17A, also known as S-AKAP84, is a mitochondrial scaffold protein that binds PKA and regulates mitochondrial function, including ATP production and apoptosis. AKAP17A primarily anchors PKA to the mitochondrial membrane, facilitating cAMP-dependent signaling pathways that control oxidative phosphorylation and energy homeostasis. It has a role in maintaining mitochondrial integrity during cellular stress by regulating apoptosis signaling, including interactions with pro- and anti-apoptotic proteins like Bcl-2 and caspases. AKAP17A is expressed in tissues with high energy demands, such as cardiac and skeletal muscle, where it enhances mitochondrial respiration. Dysregulation of AKAP17A impairs mitochondrial dynamics, contributing to metabolic disorders, neurodegeneration, and cardiovascular diseases. AKAP17A has also been shown to interact with mitochondrial DNA-binding proteins, influencing mitochondrial biogenesis and replication under stress conditions.
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