Human Agouti Related Protein (AGRP) Protein

Este producto es parte de AGRP - Agouti Related Neuropeptide
Human Agouti Related Protein (AGRP) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein AGRP

proveedor

Abbexa

reference

abx065197

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Agouti Related Protein (AGRP) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Agouti-related neuropeptide (AGRP) is a peptide hormone primarily produced in the arcuate nucleus of the hypothalamus in the brain. AGRP plays a crucial role in regulating appetite and energy balance by acting as an antagonist to the melanocortin receptors, particularly the melanocortin-4 receptor (MC4R). By inhibiting MC4R activity, AGRP increases appetite and promotes feeding behavior, leading to weight gain and adiposity. Dysregulation of AGRP signaling has been in obesity and metabolic disorders. Additionally, AGRP neurons are sensitive to nutritional cues and hormonal signals, allowing them to integrate various inputs to modulate feeding behavior accordingly. Pharmacological targeting of AGRP signaling holds promise for the treatment of obesity and related metabolic conditions. Research into the molecular mechanisms underlying AGRP function provides insights into appetite regulation and potential therapeutic avenues for obesity management. Ongoing studies continue to elucidate the complex roles of AGRP in energy homeostasis and metabolic health.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Agouti Related Protein (AGRP)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 13.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly20-Ser130 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

AGRP


dry ice

No


availability

Shipped within 5-7 working days.


alias

AGRT,ART,ASIP2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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