Human Adhesion Molecule With Ig Like Domain Protein 1 (AMIGO1) Protein
221€ (10 µg)
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935106861
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name
Human Adhesion Molecule With Ig Like Domain Protein 1 (AMIGO1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650826
tested applications
WB, SDS-PAGE
Description
Human AMIGO1 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Adhesion Molecule With Ig Like Domain Protein 1 (AMIGO1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 43.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly28-Thr372 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86WK6 |
| Alias | AMIGO-1,Alivin-2 |
| Background | Protein AMIGO1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AMIGO1 is a cell adhesion molecule belonging to the AMIGO family, which is involved in neuronal development, axon guidance, and synaptic formation. AMIGO1 is highly expressed in the central nervous system (CNS), where it mediates neurite outgrowth and contributes to axon fasciculation during neural circuit formation. It interacts with other cell adhesion molecules and extracellular matrix proteins to promote cell-cell and cell-extracellular interactions critical for proper neuronal connectivity. AMIGO1 has also been implicated in synaptic plasticity and stability, supporting learning, memory, and neural repair. Dysregulation of AMIGO1 has been associated with neurodegenerative diseases such as Alzheimer’s disease, where axonal damage and synaptic dysfunction are observed. In addition to its neuronal roles, emerging evidence suggests that AMIGO1 may influence tumor progression, as its expression can promote cell migration and invasion in certain cancers. This highlights its dual significance in both neural development and disease pathology.
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