Adhesion Molecule With Ig Like Domain 1 (AMIGO1) Antibody

Product specifications

Primary Antibodies

Adhesion Molecule With Ig Like Domain 1 (AMIGO1)

Rabbit

Human, Mouse, Rat

ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by antigen affinity column chromatography.

100 µg

1 mg

Lyophilized

ELISA, WB, IHC

Prior to lyophilization: 1% BSA and 0.02% NaN3.

Shipped within 7-15 working days.

Store at -20 °C. Avoid repeated freeze/thaw cycles.

No

NM_020703

AMIGO-1,Alivin-2

Antibody anti-AMIGO1

RUO

Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. - 

Descripción

AMIGO1 is a cell adhesion molecule belonging to the AMIGO family, which is involved in neuronal development, axon guidance, and synaptic formation. AMIGO1 is highly expressed in the central nervous system (CNS), where it mediates neurite outgrowth and contributes to axon fasciculation during neural circuit formation. It interacts with other cell adhesion molecules and extracellular matrix proteins to promote cell-cell and cell-extracellular interactions critical for proper neuronal connectivity. AMIGO1 has also been implicated in synaptic plasticity and stability, supporting learning, memory, and neural repair. Dysregulation of AMIGO1 has been associated with neurodegenerative diseases such as Alzheimer’s disease, where axonal damage and synaptic dysfunction are observed. In addition to its neuronal roles, emerging evidence suggests that AMIGO1 may influence tumor progression, as its expression can promote cell migration and invasion in certain cancers. This highlights its dual significance in both neural development and disease pathology.

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