Adhesion Molecule With Ig Like Domain 1 (AMIGO1) Antibody
292.5€ (80 µl)
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935106861
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name
Adhesion Molecule With Ig Like Domain 1 (AMIGO1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx027533
tested applications
ELISA, WB
Description
AMIGO1 promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adhesion Molecule With Ig Like Domain 1 (AMIGO1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86WK6 |
| Alias | AMIGO-1,Alivin-2 |
| Background | Antibody anti-AMIGO1 |
| Status | RUO |
Descripción
AMIGO1 is a cell adhesion molecule belonging to the AMIGO family, which is involved in neuronal development, axon guidance, and synaptic formation. AMIGO1 is highly expressed in the central nervous system (CNS), where it mediates neurite outgrowth and contributes to axon fasciculation during neural circuit formation. It interacts with other cell adhesion molecules and extracellular matrix proteins to promote cell-cell and cell-extracellular interactions critical for proper neuronal connectivity. AMIGO1 has also been implicated in synaptic plasticity and stability, supporting learning, memory, and neural repair. Dysregulation of AMIGO1 has been associated with neurodegenerative diseases such as Alzheimer’s disease, where axonal damage and synaptic dysfunction are observed. In addition to its neuronal roles, emerging evidence suggests that AMIGO1 may influence tumor progression, as its expression can promote cell migration and invasion in certain cancers. This highlights its dual significance in both neural development and disease pathology.
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