Human Adenylate Kinase 3 (AK3) Protein
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Description
Adenylate Kinase 3 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Adenylate Kinase 3 (AK3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 28.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu8-Pro227 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AK3L1,AK6,AKL3L |
| Background | Protein AK3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AK3 is localized within the mitochondrial matrix and utilizes GTP as a phosphate donor instead of ATP, distinguishing it from other AK isoforms. AK3 primarily supports mitochondrial nucleotide exchange, particularly during periods of cellular energy stress. It is abundant in tissues with high-energy demands, such as the brain, liver, and kidneys. AK3 contributes to mitochondrial respiration by facilitating ADP recycling necessary for oxidative phosphorylation. Knockout studies demonstrate that AK3 deficiency disrupts ATP synthesis and exacerbates oxidative stress, which can contribute to neurodegenerative conditions. AK3 has also been implicated in regulating mitochondrial dynamics and maintaining redox balance.
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