GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody
195€ (20 µl)
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Name
GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx003544
Tested Applications
ELISA, WB
Description
AK3 Antibody is a Rabbit Polyclonal antibody against AK3. The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Immunogen: Recombinant protein corresponding to AK3. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 26 kDa Observed MW: 26 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UIJ7 |
| Gene ID | 50808 |
| NCBI Accession | NP_057366.2 |
| Alias | AK3L1,AK6,AKL3L |
| Background | Antibody anti-AK3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AK3 is localized within the mitochondrial matrix and utilizes GTP as a phosphate donor instead of ATP, distinguishing it from other AK isoforms. AK3 primarily supports mitochondrial nucleotide exchange, particularly during periods of cellular energy stress. It is abundant in tissues with high-energy demands, such as the brain, liver, and kidneys. AK3 contributes to mitochondrial respiration by facilitating ADP recycling necessary for oxidative phosphorylation. Knockout studies demonstrate that AK3 deficiency disrupts ATP synthesis and exacerbates oxidative stress, which can contribute to neurodegenerative conditions. AK3 has also been implicated in regulating mitochondrial dynamics and maintaining redox balance.
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