Human Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor (ADCYAP1R1) Protein
1079€ (50 µg)
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935106861
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name
Human Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor (ADCYAP1R1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691160
tested applications
SDS-PAGE
Description
Human ADCYAP1R1 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human ADCYAP1R1 (P41586) extracellular domain (Met 1-Ala 155) was fused with the Fc region of human IgG1 at the C-terminus.
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Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor (ADCYAP1R1) |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 42 kDa Sequence Fragment: Met1-Ala155 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 88% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41586 |
| Gene ID | 117 |
| OMIM | 102981 |
| Alias | ADCYAP1R1,PAC1R,PVR1,PACAP receptor 1,PACAP type IA receptor,PACAPR1,pituitary adenylate cyclase activating polypeptide 1 receptor,PACAP1-R,adenylate cyclase activating polypeptide 1 receptor 1,adenylate cyclase activating polypeptide 1 receptor type 1,ADCYAP receptor type 1,PAC1,PACAPR, PACAPRI |
| Background | Protein ADCYAP1R1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The ADCYAP1R1 gene encodes the PAC1 receptor, which belongs to the class B G-protein-coupled receptor (GPCR) family. This receptor is the primary target of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a neuropeptide that regulates various physiological processes. ADCYAP1R1 is widely expressed in the central nervous system (CNS), endocrine glands, and peripheral tissues. Upon PACAP binding, it activates adenylyl cyclase and stimulates the production of cyclic AMP (cAMP), leading to downstream signal transduction. ADCYAP1R1 plays critical roles in neuroprotection, stress response, metabolism, and immune regulation. Dysregulation of this receptor has been linked to neurological disorders, anxiety, depression, and inflammatory diseases, underscoring its importance in maintaining physiological homeostasis.
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