Human Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor (ADCYAP1R1) Protein
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935106861
info@markelab.com
Precio
871€ (50 µg)
Protein ADCYAP1R1
proveedor
Abbexareference
abx691160Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Human ADCYAP1R1 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human ADCYAP1R1 (P41586) extracellular domain (Met 1-Ala 155) was fused with the Fc region of human IgG1 at the C-terminus.
Background
The ADCYAP1R1 gene encodes the PAC1 receptor, which belongs to the class B G-protein-coupled receptor (GPCR) family. This receptor is the primary target of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a neuropeptide that regulates various physiological processes. ADCYAP1R1 is widely expressed in the central nervous system (CNS), endocrine glands, and peripheral tissues. Upon PACAP binding, it activates adenylyl cyclase and stimulates the production of cyclic AMP (cAMP), leading to downstream signal transduction. ADCYAP1R1 plays critical roles in neuroprotection, stress response, metabolism, and immune regulation. Dysregulation of this receptor has been linked to neurological disorders, anxiety, depression, and inflammatory diseases, underscoring its importance in maintaining physiological homeostasis.
Características del producto
category
Proteins and Peptides
origin
Human
host
HEK293 cells
immunogen target
Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor (ADCYAP1R1)
host
HEK293 cells
form
tested applications
SDS-PAGE
size 1
50 µg
observerd MW
Molecular Weight: 42 kDa Sequence Fragment: Met1-Ala155 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months.
expression
Recombinant
purity
> 88% (SDS-PAGE)
buffer
Lyophilized from sterile PBS, pH 7.4.
storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
or code
ADCYAP1R1
dry ice
No
availability
Shipped within 5-15 working days.
alias
ADCYAP1R1,PAC1R,PVR1,PACAP receptor 1,PACAP type IA receptor,PACAPR1,pituitary adenylate cyclase activating polypeptide 1 receptor,PACAP1-R,adenylate cyclase activating polypeptide 1 receptor 1,adenylate cyclase activating polypeptide 1 receptor type 1,ADCYAP receptor type 1,PAC1,PACAPR, PACAPRI
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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