Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor (ADCYAP1R1) Antibody

Name: Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor (ADCYAP1R1) Antibody
Brand: Abbexa
SKU: abx002241
Price: 195 EUR
Availability: OnlineOnly

Pida mas información

935106861

info@markelab.com

Precio

195€ (20 µl)

Antibody anti-ADCYAP1R1

proveedor

Abbexa

reference

abx002241

Tested Applications

ELISA, WB, IF/ICC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

ADCYAP1R1 Antibody is a Rabbit Polyclonal antibody against ADCYAP1R1. This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.

Background

The ADCYAP1R1 gene encodes the PAC1 receptor, which belongs to the class B G-protein-coupled receptor (GPCR) family. This receptor is the primary target of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a neuropeptide that regulates various physiological processes. ADCYAP1R1 is widely expressed in the central nervous system (CNS), endocrine glands, and peripheral tissues. Upon PACAP binding, it activates adenylyl cyclase and stimulates the production of cyclic AMP (cAMP), leading to downstream signal transduction. ADCYAP1R1 plays critical roles in neuroprotection, stress response, metabolism, and immune regulation. Dysregulation of this receptor has been linked to neurological disorders, anxiety, depression, and inflammatory diseases, underscoring its importance in maintaining physiological homeostasis.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse, Rat

immunogen target

Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor (ADCYAP1R1)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IF/ICC

purification

Purified by affinity chromatography.

recommended dilution

ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.

size 1

20 µl

size 2

100 µl

size 3

2 × 100 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

ADCYAP1R1

dry ice

availability

Shipped within 5-10 working days.

alias

ADCYAP1R1,PAC1R,PVR1,PACAP receptor 1,PACAP type IA receptor,PACAPR1,pituitary adenylate cyclase activating polypeptide 1 receptor,PACAP1-R,adenylate cyclase activating polypeptide 1 receptor 1,adenylate cyclase activating polypeptide 1 receptor type 1,ADCYAP receptor type 1,PAC1,PACAPR, PACAPRI

uniprot id

https://www.uniprot.org/uniprotkb/P41586

gene id

https://www.ncbi.nlm.nih.gov/gene/117

NCBI accession

NP_001109.2

note

Concentration: > 0.2 mg/ml -

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Human ADCYAP1R1(Pituitary adenylate cyclase-activating polypeptide type I receptor) ELISA Kit

proveedor

FineTest

reference

EH1765

reactivity

human

status

RUO

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