Human Adenylate Cyclase Type 8 (ADCY8) Protein
247€ (10 µg)
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935106861
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name
Human Adenylate Cyclase Type 8 (ADCY8) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167169
tested applications
WB, SDS-PAGE
Description
Adenylate Cyclase Type 8 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Adenylate Cyclase Type 8 (ADCY8) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 45.3 kDa Observed MW (SDS-PAGE): 48 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys234-Glu371 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P40145 |
| Gene ID | 114 |
| OMIM | 103070 |
| Alias | AC8,ADCY3,HBAC1 |
| Background | Protein ADCY8 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADCY8 is a calcium/calmodulin-activated enzyme predominantly expressed in the brain, particularly in regions involved in synaptic plasticity and memory formation. It plays a key role in generating cAMP in response to elevated calcium levels, thereby regulating neuronal excitability and synaptic strength. ADCY8 is involved in processes such as learning, memory, and mood regulation. Dysregulation of ADCY8 has been linked to neurological disorders, including depression and cognitive decline, due to impaired calcium-dependent cAMP signaling.
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